The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment continues, and may be minimized by bedtime administration of ACTIMMUNE.At doses 10 times greater than the weekly recommended dose, ACTIMMUNE may exacerbate pre-existing cardiac conditions, or may cause reversible neurological effects such as decreased mental status, gait disturbance, and dizziness.Reversible neutropenia, thrombocytopenia, and elevations of AST and/or ALT have been observed during ACTIMMUNE therapy.Isolated cases of acute serious hypersensitivity reactions have been observed in patients receiving ACTIMMUNE.Acetaminophen may be used to prevent or partially alleviate the fever and headache Avoid simultaneous administration of ACTIMMUNE with other heterologous serum protein or immunological preparations.Concomitant use of drugs with neurotoxic, hematotoxic, or cardiotoxic effects may increase the toxicity of interferons.Long-term effects of ACTIMMUNE on fertility are not known.ACTIMMUNE or nursing should be discontinued dependent on the importance of the drug to the mother Use of ACTIMMUNE by lactating mothers is not recommended.ACTIMMUNE should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. ![]() Renal toxicity has been reported in patients receiving ACTIMMUNE Monitor renal function regularly when administering ACTIMMUNE in patients with severe renal insufficiency accumulation of interferon gamma-1b may occur with repeated administration.If severe hepatic enzyme elevations develop, ACTIMMUNE dosage should be modified Therefore, the investigators will conduct an early phase 2, multi-center, open-label, 12-month clinical trial of ACTIMMUNE (IFN-1b) treatment of patients with intermediate osteopetrosis to determine the following: The feasibility and tolerability of interferon gamma-1b treatment for 1 year in patients with intermediate osteopetrosis. Patients begun on ACTIMMUNE before age 1 year should receive monthly assessments of liver function. ![]()
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